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  • Title: Activin synergistically increased c-jun mRNA in P19 embryonal carcinoma cells in the presence of retinoic acid.
    Author: Momoi T, Kawai Y, Momoi M, Etoh Y.
    Journal: Biochem Biophys Res Commun; 1992 May 15; 184(3):1350-6. PubMed ID: 1590797.
    Abstract:
    Activin and retinoids, which are involved in the induction and regulation of the early differentiation process in vertebrate embryogenesis, synergistically increased the amount of c-jun mRNA in P19 embryonal carcinoma cells, but activin alone had no effect. Among the retinoids, all-trans-retinoic acid most effectively increased c-jun mRNA. Activin (lng/ml) was sufficient to induce the synergistic increase of c-jun mRNA in P19 EC cells with all-trans-retinoic acid. The synergistic increase of the amount of c-jun mRNA by their cooperative action may be important in vertebrate development.
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