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  • Title: Cloning and modulation by endothelin-1 of rat cardiac K channel.
    Author: Ishii K, Nunoki K, Murakoshi H, Taira N.
    Journal: Biochem Biophys Res Commun; 1992 May 15; 184(3):1484-9. PubMed ID: 1590805.
    Abstract:
    We have cloned a delayed rectifier type K channel from rat heart (RH1). RH1 was identical to the rat brain K channel BK2 and differed from recently cloned rat cardiac K channel RAK by one amino acid residue. Endothelin receptors(ETRs)-mediated modulation of RH1 current (IRH1) was studied using Xenopus oocyte expression system. Activation of two different subtypes of ETRs by endothelin-1 equally suppressed the amplitude of IRH1. Stimulation of phosphatidylinositol turnover will probably be responsible for the suppression.
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