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  • Title: Tumor suppressor activities of the Fbw7 E3 ubiquitin ligase receptor.
    Author: Fuchs SY.
    Journal: Cancer Biol Ther; 2005 May; 4(5):506-8. PubMed ID: 15908780.
    Abstract:
    The F-box protein Fbw7/Sel-10/hCdc4/Ago, which is known to regulate ubiquitination and degradation of numerous important regulators of cell division and death including Notch, cyclin E, c-Jun and c-Myc, has been recently rediscovered as a p53-dependent tumor suppressor. Delineation of the mechanisms of Fbw7 anti-oncogenic activities and of its inactivation in human cancers is expected to gain an important insight into tumorigenesis.
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