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  • Title: [Occurrence of chloroquine-induced myopathy after low-dose treatment of rheumatoid arthritis for seven years].
    Author: Haberl A, Fischer P, Pongratz D, Sieb JP.
    Journal: Z Rheumatol; 2005 May; 64(4):274-6. PubMed ID: 15909088.
    Abstract:
    The myotoxicity of chloroquine and hydroxychloroquine has been known for decades. Limb-girdle weakness due to a vacuolar myopathy may occur occasionally in a dose-dependent manner during the first 24 months on chloroquine. However, we report on a case in which muscular weakness developed after a daily intake of 250 chloroquine phosphate (= 155 mg chloroquine base) for a period of 7 years. Even after long-term and apparently well-tolerated chloroquine treatment, the occurrence of severe side-effects is possible.
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