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  • Title: Treatment of insulinoma in a springer spaniel with streptozotocin.
    Author: Bell R, Mooney CT, Mansfield CS, Jones BR.
    Journal: J Small Anim Pract; 2005 May; 46(5):247-50. PubMed ID: 15909449.
    Abstract:
    An eight-year-old, female springer spaniel was treated for metastatic insulinoma with a single intravenous dose of 500 mg/m2 streptozotocin (SZN), and pre- and post-treatment diuresis. A tapering dose of corticosteroids was also administered over a 28 day period. SZN and corticosteroid administration resulted in resolution of hypoglycaemia and subsequent development of diabetes mellitus. Further metastases caused cervical spinal pain and the dog was euthanased 118 days after SZN administration. SZN can be safely used for the treatment of canine insulinoma, but, when compared with other published cases, a marked variation in clinical response to this drug exists and further study is warranted.
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