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  • Title: ES-62 is unable to modulate Toxoplasma gondii-driven Th1 responses and pathology.
    Author: Couper KN, Chen W, Houston KM, Harnett W, Johnson LL.
    Journal: Parasite Immunol; 2005 Apr; 27(4):147-50. PubMed ID: 15910423.
    Abstract:
    ES-62, a filarial nematode-derived anti-inflammatory immunomodulator, was administered to mice in an attempt to prevent pathology associated with Toxoplasma gondii infection. The nematode product was shown to elevate mitogen and T. gondii-specific IL-10 production but was unable to inhibit Th1 responses. Consequently ES-62 could not prevent Th1 generated immunopathology.
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