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  • Title: Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase.
    Author: Hopkins CR, Czekaj M, Kaye SS, Gao Z, Pribish J, Pauls H, Liang G, Sides K, Cramer D, Cairns J, Luo Y, Lim HK, Vaz R, Rebello S, Maignan S, Dupuy A, Mathieu M, Levell J.
    Journal: Bioorg Med Chem Lett; 2005 Jun 02; 15(11):2734-7. PubMed ID: 15911249.
    Abstract:
    A new series of novel mast cell tryptase inhibitors is reported, which features the use of an indole structure as the hydrophobic substituent on a m-benzylaminepiperidine template. The best members of this series display good in vitro activity and excellent selectivity against other serine proteases.
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