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  • Title: Nested polymerase chain reaction for assessing the clinical course of tuberculous meningitis.
    Author: Takahashi T, Nakayama T, Tamura M, Ogawa K, Tsuda H, Morita A, Hara M, Togo M, Shiota H, Suzuki Y, Minami M, Ishikawa H, Miki K, Shikata E, Takahashi S, Kuragano T, Matsumoto K, Sawada S, Mizutani T.
    Journal: Neurology; 2005 May 24; 64(10):1789-93. PubMed ID: 15911814.
    Abstract:
    The authors examined the usefulness of nested PCR (N-PCR) to detect Mycobacterium tuberculosis (MTB) DNA in CSF for assessing the clinical course of tuberculous meningitis (TBM). N-PCR successfully detected MTB DNA in all nine CSF samples from patients with suspected TBM. During anti-tuberculosis treatments, N-PCR results converted from positive to negative, correlating with the improvement of the patient's clinical condition.
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