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  • Title: A cross-reactive tick cement antigen is a candidate broad-spectrum tick vaccine.
    Author: Trimnell AR, Davies GM, Lissina O, Hails RS, Nuttall PA.
    Journal: Vaccine; 2005 Jul 29; 23(34):4329-41. PubMed ID: 15913855.
    Abstract:
    Truncated constructs of 64P (64TRPs), a secreted cement protein from salivary glands of the tick Rhipicephalus appendiculatus, provided cross-protection against Rhipicephalus sanguineus and Ixodes ricinus, apparently by targeting antigens in the midgut and salivary glands of adults and nymphs, causing mortality. Tick feeding on 64TRP-immunised animals stimulated local inflammatory immune responses (involving basophils, eosinophils, lymphocytes, mast cells, macrophages and dendritic-like cells) that boosted the immune status of vaccinated animals. The vaccine trial results, and antigenic cross-reactivity of 64TRPs with R. sanguineus, I. ricinus, Amblyomma variegatum and Boophilus microplus, indicate the potential of 64TRPs as a broad-spectrum anti-tick vaccine.
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