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  • Title: Reduction of diffusion-weighted MRI lesion volume after early moderate hypothermia in ischemic stroke.
    Author: Berger C, Schramm P, Schwab S.
    Journal: Stroke; 2005 Jun; 36(6):e56-8. PubMed ID: 15914760.
    Abstract:
    BACKGROUND: Large areas of restricted diffusion in the middle cerebral artery (MCA) territory are highly predictive of severe and potentially space-occupying MCA stroke. A reduction of diffusion-weighted MRI (DWI) lesions occurs in 20% to 40% of acute stroke patients with early reperfusion. METHODS: We report of a patient with a severe stroke syndrome who was treated with early moderate hypothermia but not thrombolysis. RESULTS: The initially large DWI deficit of the whole MCA territory contrasted to the relatively small final lesion restricted to the basal ganglia on MRI and computed tomography scan. CONCLUSIONS: This case describes an unexpected reduction of a DWI lesion after early moderate hypothermia and spontaneous recanalization 3 days after stroke onset. We discuss potential reasons for the unexpected DWI lesion reduction.
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