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  • Title: Sublingual specific immunotherapy reduces PBMC proliferations.
    Author: Fenoglio D, Puppo F, Cirillo I, Vizzaccaro A, Ferrera A, Tosca MA, Marseglia G, Ciprandi G.
    Journal: Eur Ann Allergy Clin Immunol; 2005 Apr; 37(4):147-51. PubMed ID: 15916016.
    Abstract:
    BACKGROUND: Subcutaneous specific immunotherapy has been demonstrated capable of inducing T regulatory response. There is few evidence concerning immunological changes induced by sublingual immunotherapy. OBJECTIVE: The aim of this study was to evaluate T cell proliferation in subjects successfully treated with SLIT for HDM. METHODS: PBMCs were isolated from patients after at least 3 years of successful HDM SLIT and from matched untreated allergic and healthy control subjects. After 3 and 6 days of in vitro stimulation with PHA, Candida albicans, Dermatophagoides farinae, grasses, Parietaria judaica, and cat, proliferation. RESULTS: Subjects treated with SLIT showed significant reduction of proliferation induced by Candida albicans, Parietaria, and grasses in comparison with untreated atopics (p=0.0002, 0.0033, and 0.009 respectively). CONCLUSION: This pilot study confirms reduced T cell proliferation in allergic subjects treated with SLIT.
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