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  • Title: Light-induced fluorescence of the human cervix decreases after prostaglandin application for induction of labor at term.
    Author: Fittkow CT, Maul H, Olson G, Martin E, MacKay LB, Saade GR, Garfield RE.
    Journal: Eur J Obstet Gynecol Reprod Biol; 2005 Nov 01; 123(1):62-6. PubMed ID: 15916844.
    Abstract:
    OBJECTIVE: To define the changes in cervical light-induced fluorescence (LIF), an index of cross-linked collagen, after the use of locally applied prostaglandin preparations for labor induction at term and the correlation between LIF and Bishop-Score. STUDY DESIGN: The characteristic LIF of cervical collagen was measured from the surface of the cervix using a specially designed instrument (collascope) in 41 gravidas undergoing labor induction at term by prostaglandins. LIF and Bishop-Score were obtained directly before and 4h after the administration of prostaglandin. Paired Student's t-test, Wilcoxon Signed Rank test, Linear Regression, Spearman correlation and Fisher Exact test were used as appropriate. RESULTS: Cervical LIF decreased significantly after prostaglandin application (0.982+/-0.04 [before] to 0.885+/-0.037 [after], p=0.025). The decrease in LIF correlated with the initial LIF before PG-application (r=0.61). The Bishop-Score increased in all 41 patients. No correlation was found between LIF versus Bishop-Score. CONCLUSIONS: Cervical application of prostaglandins decreases the amount of cross-linked collagen as measured by LIF. This effect was observed only in patients with a prior high cross-linked collagen.
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