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  • Title: Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?
    Author: Fuchs BC, Bode BP.
    Journal: Semin Cancer Biol; 2005 Aug; 15(4):254-66. PubMed ID: 15916903.
    Abstract:
    Relative to other neutral amino acid transporters, the expression levels of ASCT2 and LAT1, are coordinately elevated in a wide spectrum of primary human cancers, suggesting that they are frequently co-opted to support the "tumor metabolome". Each has recently been shown to play important roles in the growth and survival of cancer cell lines, making them potential targets for cancer therapy. The properties and putative relationship of these two amino acid exchangers are discussed in the context of their demonstrated utility in cancer biology, including cellular growth and survival signaling and integrated links to the mammalian target-of-rapamycin (mTOR) kinase.
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