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  • Title: In vitro activity of doripenem (S-4661) against multidrug-resistant gram-negative bacilli isolated from patients with cystic fibrosis.
    Author: Chen Y, Garber E, Zhao Q, Ge Y, Wikler MA, Kaniga K, Saiman L.
    Journal: Antimicrob Agents Chemother; 2005 Jun; 49(6):2510-1. PubMed ID: 15917558.
    Abstract:
    Doripenem 50% inhibitory concentrations (MIC50) and 90% inhibitory concentrations (MIC90) for multidrug-resistant strains of mucoid Pseudomonas aeruginosa (n=200 strains), nonmucoid P. aeruginosa (n=200), and Burkholderia cepacia complex (n=200) isolated from patients with cystic fibrosis were 8 and 32, 8 and 64, and 8 and 32 microg/ml, respectively. Doripenem had somewhat better activity than established antimicrobial agents.
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