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  • Title: Structure and antitumor activity of a branched (1----3)-beta-D-glucan from the alkaline extract of Amanita muscaria.
    Author: Kiho T, Katsuragawa M, Nagai K, Ukai S, Haga M.
    Journal: Carbohydr Res; 1992 Feb 07; 224():237-43. PubMed ID: 1591764.
    Abstract:
    A beta-(1----6)-branched (1----3)-beta-D-glucan(AM-ASN) was isolated from the alkaline extract of the fruiting bodies of Amanita muscaria. AM-ASN had [alpha]D - 11 degrees in 0.5 M sodium hydroxide. Its estimated molecular weight was 95,000 in this alkaline solution and 260,000 in a neutral solution. The branches in the glucan were primarily single, (1----6)-linked D-glucopyranosyl groups, two for every seven residues in the (1----3)-linked main chain. AM-ASN exhibited significant antitumor activity against Sarcoma 180 in mice, and a mixture of AM-ASN with mitomycin C was more effective against the tumor than mitomycin C only.
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