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  • Title: Presynaptic calcium stores and synaptic transmission.
    Author: Collin T, Marty A, Llano I.
    Journal: Curr Opin Neurobiol; 2005 Jun; 15(3):275-81. PubMed ID: 15919193.
    Abstract:
    Following the gradual recognition of the importance of intracellular calcium stores for somatodendritic signaling in the mammalian brain, recent reports have also indicated a significant role of presynaptic calcium stores. Ryanodine-sensitive stores generate local, random calcium signals that shape spontaneous transmitter release. They amplify spike-driven calcium signals in presynaptic terminals, and consequently enhance the efficacy of transmitter release. They appear to be recruited by an association with certain types of calcium-permeant ion channels, and they induce specific forms of synaptic plasticity. Recent research also indicates a role of inositoltrisphosphate-sensitive presynaptic calcium stores in synaptic plasticity.
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