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  • Title: Cytotoxic sesquiterpene lactones from Eupatorium kiirunense, a coastal plant of Taiwan.
    Author: Shen YC, Lo KL, Kuo YH, Khalil AT.
    Journal: J Nat Prod; 2005 May; 68(5):745-50. PubMed ID: 15921421.
    Abstract:
    Phytochemical investigation of Eupatorium kiirunense has resulted in the isolation of eight new sesquiterpene lactones, constituted by five germacranolides, eupakirunsins A-E (1-5), and three heliangolides, eupaheliangolide A (6), 15-acetoxyheliangin (7), and 3-epi-heliangin (8), in addition to the known heliangin (9) and 8,10-epoxy-9-acetoxythymol angelate (10). The structures of the new compounds were established through detailed analysis of their spectroscopic data. Compounds 6, 8, and 9 exhibited cytotoxicity against human oral epidermoid (KB), cervical epitheloid (Hela), and liver (hepa59T/VGH) carcinoma cells.
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