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  • Title: Pseudoguanolide sesquiterpene lactones from Vernoniopsis caudata and their in vitro antiplasmodial activities.
    Author: Ramanandraibe V, Martin MT, Rakotondramanana DL, Mambu L, Ramanitrahasimbola D, Labaïed M, Grellier P, Rasoanaivo P, Frappier F.
    Journal: J Nat Prod; 2005 May; 68(5):800-3. PubMed ID: 15921436.
    Abstract:
    Two new helenanolide sesquiterpene lactones, 1 and 2, as well as one known related structure, 11alpha,13-dihydrohelenalin-[2-(1-hydroxyethyl)acrylate] (3), together with 4'-beta-d-O-glucopyranosyl-luteolin and ethyl 2,5-dihydroxycinnamate were isolated from an ethyl acetate extract of leaves of Vernoniopsis caudatawith potent antiplasmodial activity (IC50 1.6 microg/mL) in a preliminary biological screen. The structures of the new compounds were determined by spectroscopic techniques. The three sesquiterpene lactones 1-3 displayed strong in vitro antiplasmodial activity, with IC50 values of 1, 0.19, and 0.41 microM, respectively. However, these compounds also exhibited considerable cytotoxicity on KB cells (IC50 < 1 microM in each case).
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