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  • Title: Paecilosetin, a new bioactive fungal metabolite from a New Zealand isolate of Paecilomyces farinosus.
    Author: Lang G, Blunt JW, Cummings NJ, Cole AL, Munro MH.
    Journal: J Nat Prod; 2005 May; 68(5):810-1. PubMed ID: 15921439.
    Abstract:
    A new tetramic acid derivative, paecilosetin (1), along with a recently characterized N-hydroxypyridone, farinosone B (2), was isolated from the fungus Paecilomyces farinosus. Each compound showed activity against the P388 cell line with IC50 values of 3.1 and 1.1 microg/mL, respectively. Paecilosetin was also active against the microorganisms Bacillus subtilis, Trichophyton mentagrophytes, and Cladosporium resinae.
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