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  • Title: An anti-staphylococcal acylphloroglucinol from Hypericum foliosum.
    Author: Gibbons S, Moser E, Hausmann S, Stavri M, Smith E, Clennett C.
    Journal: Phytochemistry; 2005 Jun; 66(12):1472-5. PubMed ID: 15921710.
    Abstract:
    An investigation into the antibacterial properties of Hypericum foliosum Aiton. (Guttiferae) has led to the isolation of a new bioactive acylphloroglucinol natural product which by NMR spectroscopy and mass spectrometry was characterised as 1,3,5-trihydroxy-6-[2''',3'''-epoxy-3'''-methyl-butyl]-2-[2''-methyl-butanoyl]-4-[3'-methyl-2''-butenyl]-benzene and is described here for the first time. This metabolite was evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus and minimum inhibitory values ranged from 16 to 32 microg/ml.
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