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  • Title: Techniques used to freeze-dry "small doses" of thrombin.
    Author: Jaffe DR, Samyn JC, Sheehan G.
    Journal: Dev Biol Stand; 1992; 74():211-3; discussion 213-4. PubMed ID: 1592172.
    Abstract:
    In can be difficult to maintain the moisture level of small quantities of freeze-dried product contained in vials. We have observed that over a period of time a gradual increase in the residual moisture level in Thrombin vials containing small quantities of the freeze-dried product can sometimes be seen. No change in Thrombin potency has been observed. Investigations into the cause and resolution of this situation resulted in (1) modification of the freeze-drying cycle for vials containing small quantities of Thrombin and (2) incorporation of a special drying cycle for vial stoppers.
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