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  • Title: GDIs: central regulatory molecules in Rho GTPase activation.
    Author: DerMardirossian C, Bokoch GM.
    Journal: Trends Cell Biol; 2005 Jul; 15(7):356-63. PubMed ID: 15921909.
    Abstract:
    The GDP dissociation inhibitors (GDIs) are pivotal regulators of Rho GTPase function. GDIs control the access of Rho GTPases to regulatory guanine nucleotide exchange factors and GTPase-activating proteins, to effector targets and to membranes where such effectors reside. We discuss here our current understanding of how Rho GTPase-GDI complexes are regulated by various proteins, lipids and enzymes that exert GDI displacement activity. We propose that phosphorylation mediated by diverse kinases might provide a means of controlling and coordinating Rho GTPase activation.
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