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  • Title: Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation.
    Author: Zhang RX, Wang L, Liu B, Qiao JT, Ren K, Berman BM, Lao L.
    Journal: Brain Res; 2005 Jun 28; 1048(1-2):235-40. PubMed ID: 15922310.
    Abstract:
    Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm-sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifically decreases MOR and blocks EA anti-hyperalgesia. These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia.
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