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  • Title: Fundoplication eliminates chronic cough due to non-acid reflux identified by impedance pH monitoring.
    Author: Mainie I, Tutuian R, Agrawal A, Hila A, Highland KB, Adams DB, Castell DO.
    Journal: Thorax; 2005 Jun; 60(6):521-3. PubMed ID: 15923255.
    Abstract:
    The symptoms of extra-oesophageal gastro-oesophageal reflux disease (GORD) (such as chronic cough and hoarseness) are traditionally more difficult to treat than typical GORD symptoms (heartburn and regurgitation). Patients with extra-oesophageal manifestations may require longer and higher doses of acid suppressive therapy. In patients not responding to acid suppressive therapy the physician faces a dilemma as to whether the symptoms are due to ongoing acid reflux, non-acid reflux, or not associated with reflux. We report the case of a 45 year old woman with a history of a chronic cough referred for fundoplication after documenting her symptoms were associated with non-acid reflux using multichannel intraluminal impedance and pH (MII-pH).
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