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  • Title: [Effect of glycine and strychnine on Cl(-)-activated Mg2+-ATPase from bream brain microsomes (Abamis brama L.)].
    Author: Menzikov SA, Menzikova OV.
    Journal: Izv Akad Nauk Ser Biol; 2001; (6):760-3. PubMed ID: 15926343.
    Abstract:
    The effect of glycine and strychnine on Mg2+-ATPase from the microsomal fraction of the bream (Abramis brama L.) brain was studied. The glycine in the concentration range 10(-7)-10(-4) M activates the enzyme. The effect of glycine on Mg2+-ATPase is obviated by 100 microM strychnine. The strychnine in the concentration range 5-90 microM activates the basal Mg2+-ATPase but decreases the effect of the enzyme activation by 10(-4) M glycine. The effect of Cl- on Mg2+-ATPase depends on the substrate concentration (Mg2+-ATP) and is not observed in the presence of 100 microM strychnine. A receptor-dependent pathway of glycine and strychnine action on Cl(-)-activated Mg2+-ATPase from bream brain microsomes is proposed.
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