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  • Title: Alkali-labile sites and post-irradiation effects in gamma-irradiated biologically active double-stranded DNA in aqueous solution.
    Author: Lafleur MV, Woldhuis J, Loman H.
    Journal: Int J Radiat Biol Relat Stud Phys Chem Med; 1979 Sep; 36(3):241-7. PubMed ID: 159268.
    Abstract:
    Gamma-irradiation of double-stranded RF-DNA of bacteriophage phi X174 in aqueous solution in the presence of oxygen produces at least one type of alkali-labile site. It is lethal and gives rise to breaks by alkali and is identical with the damage which becomes manifest by post-irradiation heat treatment. The effect of alkali is dependent on temperature. Furthermore, the excision repair system is not involved in eliminating lethal nucleotide damage in RFI-DNA.
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