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  • Title: Cytotoxic effects of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine in cross-resistant H9 human lymphoma cells.
    Author: Saiko P, Horvath Z, Illmer C, Madlener S, Bauer W, Hoechtl T, Erlach N, Grusch M, Krupitza G, Mader RM, Jaeger W, Schott H, Agarwal RP, Fritzer-Szekeres M, Szekeres T.
    Journal: Leuk Res; 2005 Jul; 29(7):785-91. PubMed ID: 15927674.
    Abstract:
    Various amphiphilic heterodinucleoside phosphates have recently been synthesized in order to overcome drug resistance. These agents contain 5-fluorodeoxyuridine (5-FdUrd) and arabinofuranosylcytosine (Ara-C). We now investigated the action of two of these novel dimers (#2 and #10) in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. The dimers were compared with 5-FdUrd and Ara-C for growth inhibition, apoptosis induction, and cell-cycle effects. No significant difference in the cytotoxicity of dimer #2 could be observed between sensitive and 5-FdUrd/Ara-C cross-resistant H9 cells (IC50 values of 220 nM and 200 nM, respectively), indicating that further studies with this compound are warranted.
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