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  • Title: Bacillus subtilis YabA is involved in determining the timing and synchrony of replication initiation.
    Author: Hayashi M, Ogura Y, Harry EJ, Ogasawara N, Moriya S.
    Journal: FEMS Microbiol Lett; 2005 Jun 01; 247(1):73-9. PubMed ID: 15927750.
    Abstract:
    It is shown here by flow cytometry that Bacillus subtilis YabA negatively regulates the timing of replication initiation. When the level of YabA was reduced, replication began at a decreased cell mass and when the level was increased, initiation was delayed. Synchrony of replication initiation was also disrupted at low levels of YabA. Yfp-YabA localized as foci in cells. Since YabA was reported to interact with DnaN (beta subunit of DNA polymerase III), co-localization of Yfp-YabA with the polymerase was examined using a Cfp fusion with DnaX (tau subunit of DNA polymerase III). It is reported that YabA appears to localize at the replication forks only at a late stage of DNA replication.
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