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  • Title: Promotion of stable triplex formation by partial incorporation of 2',5'-phosphodiester linkages into triplex-forming oligonucleotides.
    Author: Obika S, Hiroto A, Nakagawa O, Imanishi T.
    Journal: Chem Commun (Camb); 2005 Jun 14; (22):2793-5. PubMed ID: 15928760.
    Abstract:
    Pentadecamer homopyrimidine oligonucleotides containing three or more 2',5'-phosphodiester linkages in different modes were prepared and used to evaluate the ability as a triplex-forming oligonucleotide (TFO), and it was found that discontinuous replacement of the 3',5'-phosphodiester linkages in TFO by 2',5'-linkages significantly stabilizes parallel-motif triplexes.
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