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  • Title: L-carnitine supplementation does not promote weight loss in ovariectomized rats despite endurance exercise.
    Author: Melton SA, Keenan MJ, Stanciu CE, Hegsted M, Zablah-Pimentel EM, O'Neil CE, Gaynor P, Schaffhauser A, Owen K, Prisby RD, LaMotte LL, Fernandez JM.
    Journal: Int J Vitam Nutr Res; 2005 Mar; 75(2):156-60. PubMed ID: 15929637.
    Abstract:
    In this five-week study, we tested the hypotheses that free access to a maintenance diet supplemented with L-carnitine (L-C) would reduce body fat in adult, sedentary, ovariectomized (OVX) rats, and that there would be an additive effect of L-C on weight reduction in swim-trained animals. As expected, serum carnitine was higher in rats fed the L-C diet, and the OVX-induced weight gain and abdominal fat were counteracted by swimming. L-C supplementation did not reduce the weight gain or abdominal fat in these adult female rats, Moreover, though not reaching statistical significance, rats that were fed L-C demonstrated a tendency for greater weight gain than their basal-fed counterparts despite no difference in energy intake. If the results of this study on ovariectomized rats can be translated to postmenopausal women, moderate intensity exercise may be recommended, but L-C supplementation, with no energy restriction, may be contraindicated as a weight loss method in this cohort.
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