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  • Title: Preparation and characterization of a novel pH-sensitive ion exchange resin.
    Author: Liu H, Zhang S, Nie S, Zhao X, Sun X, Yang X, Pan W.
    Journal: Chem Pharm Bull (Tokyo); 2005 Jun; 53(6):631-3. PubMed ID: 15930772.
    Abstract:
    Methylacrylic acid/styrene cross-linked with divinylbenzene is a novel pH-sensitive ion exchange resin. Microspheres of this resin were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The microspheres showed a pulsatile swelling behavior when the pH of the media changed. The pH-sensitive microspheres were loaded with salbutamol sulfate and the drug-release characteristics were studied under both simulated gastric and intestinal pH conditions. The results obtained showed that the drug release also depended on the pH of the release media.
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