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  • Title: The pathogenesis and characterization of oral mucositis associated with cancer therapy.
    Author: Dodd M.
    Journal: Oncol Nurs Forum; 2004 Jul 01; 31(4 Suppl):5-11. PubMed ID: 15931274.
    Abstract:
    PURPOSE/OBJECTIVES: To describe the current knowledge about the pathogenesis of oral mucositis associated with cancer therapy and oral mucositis. DATA SOURCES: Published research and literature review articles, books, and posters of findings that have been selected for presentation at research conferences. DATA SYNTHESIS: Aggressive cancer treatment yields gains in cure or sustained control but also in oral complications, including oral mucositis. Recent work suggests that oral mucositis involves a series of biologically and physiologically complex cellular and tissue interactions that vary in accordance with treatment type and characteristics. CONCLUSIONS: The impact of treatment-related oral mucositis in patients is multifaceted and can significantly affect patients' experiences in terms of morbidity and treatment course. The creation of effective, targeted management strategies ultimately relies on a better understanding of the biologic processes underlying oral mucositis development coupled with systematic use of assessment tools. IMPLICATIONS FOR NURSING: Incorporating current knowledge about the pathogenesis of oral mucositis with regular use of available assessment instruments can help to ensure prompt recognition of oral manifestations and facilitate better treatment strategies.
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