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  • Title: Cell-mediated cytotoxic responses of spleen cells from mice bearing primary, chemically induced tumors.
    Author: Civin CI, Dorfman N, Eggers A, Fink K, Penvose D, Hsu CK, Wunderlich JR.
    Journal: J Immunol; 1979 Dec; 123(6):2550-7. PubMed ID: 159318.
    Abstract:
    Sarcomas were induced in C57BL/6 mice by using 3-methylcholanthrene. Spleen cells taken from these mice bearing primary, chemically induced tumors and from matched control mice were assessed for the capacity to generate cell-mediated cytotoxic cell activity after in vitro sensitization. Spleen cells from tumor-bearing mice generated strong cell-mediated cytotoxic responses against alloantigens and antigens on syngeneic cells.
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