These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis of the spirocyclic core of the prunolides using a singlet oxygen-mediated cascade sequence.
    Author: Sofikiti N, Tofi M, Montagnon T, Vassilikogiannakis G, Stratakis M.
    Journal: Org Lett; 2005 Jun 09; 7(12):2357-9. PubMed ID: 15932197.
    Abstract:
    [reaction: see text] A highly efficient and rapid four-step synthesis of the bis-spiroketal core of the prunolide natural products, starting from furan itself, is described. The key step and culmination of the synthesis, responsible for zipping up the spirocyclic core, is a singlet oxygen-orchestrated cascade sequence in which a double photooxygenation of a 1,2-difuryl alkene precursor precedes dehydration and spirocyclization to furnish the intact prunolide core.
    [Abstract] [Full Text] [Related] [New Search]