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  • Title: Influence of the carbon source on nisin production in Lactococcus lactis subsp. lactis batch fermentations.
    Author: De Vuyst L, Vandamme EJ.
    Journal: J Gen Microbiol; 1992 Mar; 138(3):571-8. PubMed ID: 1593266.
    Abstract:
    Nisin production by Lactococcus lactis subsp. lactis NIZO 22186 was studied in batch fermentation using a complex medium. Nisin production showed primary metabolite kinetics: nisin biosynthesis took place during the active growth phase and completely stopped when cells entered the stationary phase. A stringent correlation could be observed between the expression of the prenisin gene (nisA) and the synthesis of the post-translationally enzymically modified and processed mature nisin peptide. Moreover, it seemed likely that nisin had a growth control function. A physiological link is proposed between sucrose fermentation capacity and nisin production ability. Carbon source regulation appears to be a major control mechanism for nisin production.
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