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  • Title: [Significance of MMP2 and MMP9 expression in prostate cancer].
    Author: Zhang XY, Hong BF, Chen GF, Lu YL, Zhong M.
    Journal: Zhonghua Nan Ke Xue; 2005 May; 11(5):359-61, 364. PubMed ID: 15934460.
    Abstract:
    OBJECTIVE: To evaluate the significance of the expression of matrix metalloproteinases (MMPs) in prostate cancer (PCa) and its clinical association. METHODS: Fifty one cases of PCa and 10 cases of BPH were studied by immunohistochemical method using monoclonal antibodies to MMP2 and MMP9. RESULTS: There was significant correlation between MMP2 or MMP9 and pathological grade, Gleason score and PCa metastasis. CONCLUSION: The expression of MMP2 and MMP9 may play an important role in the development and metastasis of PCa.
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