These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: Targeting cellular adhesion molecules, chemokines and chemokine receptors in rheumatoid arthritis. Author: Haringman JJ, Oostendorp RL, Tak PP. Journal: Expert Opin Emerg Drugs; 2005 May; 10(2):299-310. PubMed ID: 15934868. Abstract: The development of specific targeted therapies, such as anti-TNF-alpha treatment, for chronic inflammatory disorders such as rheumatoid arthritis, has significantly improved treatment, although not all patients respond. Targeting cellular adhesion molecules and chemokines/chemokine receptors as regulators of the extravasation and migration of leukocytes may provide a novel approach for the treatment of these diseases. Moreover, the possibility of developing small-molecule antagonists offers an excellent method for the oral delivery of compounds with a short half-life.[Abstract] [Full Text] [Related] [New Search]