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  • Title: Targeting cellular adhesion molecules, chemokines and chemokine receptors in rheumatoid arthritis.
    Author: Haringman JJ, Oostendorp RL, Tak PP.
    Journal: Expert Opin Emerg Drugs; 2005 May; 10(2):299-310. PubMed ID: 15934868.
    Abstract:
    The development of specific targeted therapies, such as anti-TNF-alpha treatment, for chronic inflammatory disorders such as rheumatoid arthritis, has significantly improved treatment, although not all patients respond. Targeting cellular adhesion molecules and chemokines/chemokine receptors as regulators of the extravasation and migration of leukocytes may provide a novel approach for the treatment of these diseases. Moreover, the possibility of developing small-molecule antagonists offers an excellent method for the oral delivery of compounds with a short half-life.
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