These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Hypothalamo-pituitary-adrenal axis activity predicts disease progression in multiple sclerosis.
    Author: Gold SM, Raji A, Huitinga I, Wiedemann K, Schulz KH, Heesen C.
    Journal: J Neuroimmunol; 2005 Aug; 165(1-2):186-91. PubMed ID: 15935481.
    Abstract:
    Clinical studies have shown that groups of multiple sclerosis (MS) patients exhibit a chronically activated hypothalamo-pituitary-adrenal (HPA) axis. However, the association of HPA axis activity and disease progression in MS is unknown. In this longitudinal study over a 3-year follow-up period, we report that patients who exhibited stronger HPA reactivity at baseline were significantly more likely to experience progression as measured by the Expanded Disability Status Scale (EDSS) during the follow-up period. Furthermore, HPA axis activity correlated with progression ratings and cognitive impairment three years later. Tests of HPA axis activity may be useful biomarkers for disease progression in MS.
    [Abstract] [Full Text] [Related] [New Search]