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  • Title: In vivo optical imaging of human adenoid cystic carcinoma cell metastasis.
    Author: Xiong T, Zhang Z, Liu BF, Zeng S, Chen Y, Chu J, Luo Q.
    Journal: Oral Oncol; 2005 Aug; 41(7):709-15. PubMed ID: 15935724.
    Abstract:
    A noninvasive, whole-body, real-time fluorescence optical imaging of stable high-level green fluorescent protein (GFP)-expressing human adenoid cystic carcinoma (ACC-M-GFP) was demonstrated for in vivo visualization of metastatic behavior in nude mice. Five-week-old female nude mice were injected with ACC-M-GFP in the primary organ: submandibular gland. Metastases were only visualized by GFP expression in the lung. However, metastatic lesions of ACC-M-GFP in the lung, muscle, bladder and bony were found by imaging of GFP expression in intact mice through tail vein injection of ACC-M-GFP cells. The construction of highly fluorescent and stable GFP transfectants of ACC-M has revealed the multi-organ metastatic capability of ACC-M cells through this optical imaging.
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