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  • Title: Pathogenic roles of cardiac autoantibodies in dilated cardiomyopathy.
    Author: Okazaki T, Honjo T.
    Journal: Trends Mol Med; 2005 Jul; 11(7):322-6. PubMed ID: 15935731.
    Abstract:
    Whether autoimmunity could cause dilated cardiomyopathy (DCM) was disputed for more than half a century. Autoantibodies against various cardiac antigens have been found in the sera of patients with DCM but none of these autoantibodies has been shown to have a substantial role in the development of DCM. It was recently reported that the injection of autoantibodies against cardiac troponin I (cTnI) can induce DCM in normal mice. This observation showed that autoantibodies can cause DCM and put an end to the controversy. Clinical trials of immunoglobulin-adsorption therapy for DCM have already started in Germany and the results seem promising. Here, we discuss the recent findings and possibilities of immunoglobulin-adsorption therapy for this deadly disease.
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