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  • Title: Primary dermal and eye irritability tests of hydrophobically modified hydroxypropyl methylcellulose in rabbits.
    Author: Obara S, Muto H, Kokubo H, Ichikawa N, Kawanabe M, Tanaka O.
    Journal: J Toxicol Sci; 1992 Feb; 17(1):21-9. PubMed ID: 1593659.
    Abstract:
    Primary dermal and eye irritation tests of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC, hydroxypropyl methylcellulose modified with stearylglycidylether), a new cellulose derivative used as a thickener for topical pharmaceuticals and cosmetics, were conducted in rabbits. A dispersion of HM-HPMC (3%) was applied to intact and abraded skins and reactions were observed. A very slight erythema was observed in both skins and this polymer was categorized as a "mild irritant". In the eye irritation test, with a dispersion of the same concentration, it was categorized as "marginal" in unrinsed eyes and "negative" in rinsed eyes.
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