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  • Title: Relationship between short- and long-term memory and short- and long-term extinction.
    Author: Cammarota M, Bevilaqua LR, Rossato JI, Ramirez M, Medina JH, Izquierdo I.
    Journal: Neurobiol Learn Mem; 2005 Jul; 84(1):25-32. PubMed ID: 15936680.
    Abstract:
    Both the acquisition and the extinction of memories leave short- and long-term mnemonic traces. Here, we show that in male Wistar rats, the short-term memory for a step-down inhibitory avoidance task (IA) is resistant to extinction, and that its expression does not influence retrieval or extinction of long-term memory. It has been known for some time that short- and long-term inhibitory avoidance memory involve separate and parallel processes. Here we show that, instead, short-term extinction of IA long-term memory is the first step towards its long-term extinction, and that this link requires functional NMDA receptors and protein synthesis in the CA1 region of the dorsal hippocampus at the time of the first CS-no US presentation.
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