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  • Title: Transient overexpression of the 5-HT1A receptor impairs water-maze but not hole-board performance.
    Author: Bert B, Dere E, Wilhelmi N, Kusserow H, Theuring F, Huston JP, Fink H.
    Journal: Neurobiol Learn Mem; 2005 Jul; 84(1):57-68. PubMed ID: 15936683.
    Abstract:
    Previously, we showed that mice that overexpress the 5-HT(1A) receptor transiently from embryonic to perinatal stages show reduced anxiety and changes in brain serotonin turnover as adults. Here, we investigated the long-term effects of the temporary overexpression of the 5-HT(1A) receptor during early embryonic and perinatal development on the performance in two memory tasks. In the hole-board test mice that were homozygous for the transgene showed similar behavioral habituation but increased locomotion compared to heterozygous mice. In contrast water-maze performance of homozygous mice was impaired compared to heterozygous mice. These results suggest that a transient overexpression of 5-HT(1A) receptor during embryonic and perinatal development has detrimental effects on water-maze performance at adult stages.
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