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  • Title: Effects of cytokines on the growth of cultured rabbit renal cortical tubular cells.
    Author: Kanda S, Taide M, Igawa T, Saha PK, Nishimura N, Nomata K, Kanetake H, Saito Y.
    Journal: Nihon Jinzo Gakkai Shi; 1992 Jan; 34(1):19-25. PubMed ID: 1593793.
    Abstract:
    The effects of various cytokines including interleukin-1 beta, -2, and -6, tumor necrosis factor-alpha, and granulocyte-macrophage colony stimulating factor on the DNA synthesis of cultured rabbit renal cortical tubular cells were investigated. Among these cytokines, it was found that only interleukin-1 beta could stimulate the DNA synthesis of cultured renal tubular cells, while interleukin-6 mildly suppressed the DNA synthesis of such cells. Interleukin-1 beta and -6 are produced by mesangial cells. The above results suggest that these cytokines may regulate the growth of tubular cells via the urinary flow in the nephron.
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