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  • Title: [Effect of L-arginine on the endothelium functional activity in experimental diabetes mellitus].
    Author: Sahach VF, Prysiazhna OD, Tkachenko MN, Kotsiuruba AV.
    Journal: Fiziol Zh (1994); 2005; 51(2):3-7. PubMed ID: 15943225.
    Abstract:
    The experimental data about the shift of L-arginine metabolism in the direction of activization of non-oxidizing (arginase) way under experimental diabetes mellitus are presented. This shift was proved by an increase of the ratio of arginase and NO-synthase activity and an increase of the ratio of their metabolites. The decrease of the free L-arginin contents in tissues of animals with experimental diabetes mellitus is shown. The long infusion of L-arginine results in the restoration of the endothelial function, however cessation of infusion results in a gradual reduction of this effect.
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