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  • Title: [Transformation of electrical activity in the myelinated nerve fibres of amphibia by 4-aminopyridine].
    Author: Kuznetzova IV, Evstigneev DA, Glukhova NV.
    Journal: Fiziol Zh (1994); 2005; 51(2):96-103. PubMed ID: 15943238.
    Abstract:
    Using the extracellular recording we studied the effect of 4-aminopyridine (4-AP), a potassium channel blocker on the electrical activity of the myelinated nerve fibres of amphibia Rana ridibunda Pallas. Two main types of the reaction on 4-AP were established: extension of the action potential and multi-spike response. In some cases the nerve fibres with multi-spike response generated spontaneous activity without stimulation in the form of bursts of action potentials. During repetitive stimulation 4-AP decreased after-depolarization (at the beginning of the stimulation), the posttetanic after-depolarization and the development of posttetanic after-hyperpolarization. Using the paired stimulation it was established that the spike and after-depolarization of the second action potential depended on the size of after-depolarization after the first action potential. The effects of 4-AP were strongly time-dependent.
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