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  • Title: Anticardiolipin IgG antibody and homocysteine as possible risk factors for retinal vascular occlusive disease in thai patients.
    Author: Atchaneeyasakul LO, Trinavarat A, Bumrungsuk P, Wongsawad W.
    Journal: Jpn J Ophthalmol; 2005; 49(3):211-5. PubMed ID: 15944825.
    Abstract:
    PURPOSE: To assess the role of serum anticardiolipin IgG antibody and fasting plasma homocysteine levels as risk factors for retinal vascular occlusive disease in Thai patients. METHODS: This is a retrospective, case-control study. Forty-one consecutive patients with recent onset of retinal vascular occlusive diseases were enrolled. In conjunction with a routine laboratory work up, serum anticardiolipin IgG antibody and plasma homocysteine were evaluated. Ninety volunteers without a history of retinal vascular occlusive disease were chosen as controls. RESULTS: In general, mean levels of anticardiolipin IgG antibody and homocysteine did not differ between the patients and controls. However, when the groups without a history of underlying systemic diseases were compared, there were statistically significant differences in the anticardiolipin IgG antibody level between patients and controls (mean 12.24 +/- 8.66 and 7.70 +/- 6.69 GPL units/ml, respectively) with a P value of 0.024. CONCLUSIONS: No association was found between plasma homocysteine level and retinal vascular occlusion in our patient population. A high level of anticardiolipin IgG antibody is shown to be a risk factor only in patients without a history of underlying systemic diseases. The effect of anticardiolipin IgG antibody on the development of retinal vascular occlusive disease appears to be limited and may not be a major cause.
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