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  • Title: pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.
    Author: Schaller MD, Borgman CA, Cobb BS, Vines RR, Reynolds AB, Parsons JT.
    Journal: Proc Natl Acad Sci U S A; 1992 Jun 01; 89(11):5192-6. PubMed ID: 1594631.
    Abstract:
    Expression of the Rous sarcoma virus-encoded oncoprotein, pp60v-src, subverts the normal regulation of cell growth, which results in oncogenic transformation. This process requires the intrinsic protein-tyrosine kinase activity of pp60v-src and is associated with an increase in tyrosine phosphorylation of a number of cellular proteins, candidate substrates for pp60v-src. We report here the isolation of a cDNA encoding a protein, pp125, that is a major phosphotyrosine-containing protein in untransformed chicken embryo cells and exhibits an increase in phosphotyrosine in pp60v-src-transformed chicken embryo cells. This cDNA encodes a cytoplasmic protein-tyrosine kinase which, based upon its predicted amino acid sequence and structure, is the prototype for an additional family of protein-tyrosine kinases. Immunofluorescence localization experiments show that pp125 is localized to focal adhesions; hence, we suggest the name focal adhesion kinase.
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