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  • Title: Effect of scopolamine on the electrical resistance of the paw pads of mice.
    Author: Orikasa S, Saito M, Kawashima T.
    Journal: Pharmacol Biochem Behav; 1992 Apr; 41(4):855-7. PubMed ID: 1594655.
    Abstract:
    We examined the electrical resistance of the paw pads of mice under the same conditions as used previously in studies of the passive avoidance response. Administration of scopolamine (0.05-1 mg/kg, SC) 10 or 30 min prior to placement of animals in an experimental box resulted in a profound increase in electrical resistance. In contrast, subcutaneous injection of butylscopolamine (1-20 mg/kg), diazepam (1 or 2 mg/kg), or pentobarbital (10 or 20 mg/kg) did not substantially alter subject resistance. Scopolamine may act on the CNS to induce increased paw skin resistance.
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