These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: A solid-phase approach to novel purine and nucleoside analogs. Author: Chang J, Dong C, Guo X, Hu W, Cheng S, Wang Q, Chen R. Journal: Bioorg Med Chem; 2005 Aug 01; 13(15):4760-6. PubMed ID: 15946848. Abstract: This paper describes a method for the preparation of purine analogs using the solid-phase approach. Nucleoside bases were constructed on Merrifield resin by sequential displacement of purine dichloride with amines, and after detachment, the purine analogs were condensed with d,l-ribofuranoside compounds by the Vorbrüggen method. Thereof, l-ribofuranoside was prepared from l-arabinose via the selective oxidation-reduction procedure of the 2-OH group. Some compounds exhibited moderate activity against HIV-1 in PBM cells.[Abstract] [Full Text] [Related] [New Search]